WHAT IS SEMAGLUTIDE?
Semaglutide is an injectable medication which, when used in combination with diet and exercise, helps with blood sugar control in type 2 diabetics. Semaglutide belongs to a class of medications called glucagon-like peptide-1 (GLP-1) agonists, which mimic the hormone GLP-1 in your body to lower blood sugar IeveIs after you've eaten a meal.
WHAT IS THE HORMONE GLP-1?
Glucagon-like peptide 1 (GLP-1) is a hormone that causes huge effects on the regulation of blood sugar by stimulating glucose-dependent insulin secretion. Insulin is a hormone that promotes sugar uptake by the cells, stores sugar as glycogen, promotes the building of fat, and signals the body to build skeletal muscle.In addition, GLP-1 inhibits glucagon release (which slows down the release of sugar into the blood so that you burn more fat), slows down gastric emptying (makes you feel full), and lowers the desire for food intake (because you feel full).
HOW DOES SEMAGLUTIDE WORK FOR WEIGHT LOSS?
GLP-1 agonists like Semaglutide help to control your blood sugar, but people taking them also tend to lose weight. GLP-1, the key hormone involved, slows down how fast your stomach empties food (called gastric emptying). And in addition to causing your pancreas to release insulin, Semaglutide also blocks a hormone that causes your liver to release sugar (glucagon). Together, these functions can help you feel less hungry, causing you to eat less food and lose more weight.
DOES SEMAGLUTIDE CURB YOUR APPETITE?
Yes, it’s believed that Semaglutide helps curb your appetite. In addition to slowing gastric emptying to make you feel full longer. GLP-1 also plays a direct role in how appetite is regulated.
HOW LONG DOES IT TAKE TO LOSE WEIGHT ON SEMAGLUTIDE?
With Semaglutide, you will slowly work your way up to the target dose at which time you will see the most amount of weight loss. This was the case in the clinical trials, where participants had their dose adjusted until they reached 2.5 mg dose if needed. In the phase 3 trial that measured outcomes at 20 weeks, most participants were able to reach the full dose and also lost weight as their dose was increased.
They saw additional weight loss over the remaining 48 weeks at the full dose. It is important to keep in mind that weight loss can take time, and you'll see the best results when you are using your medication in combination with a healthy diet and exercise. Sometimes the medication may not work for you, or you may not be able to tolerate the full dose due to side effects in which case your practitioner will provide additional options or change the protocol to better suit your individual needs.
HOW LONG SHOULD YOU TAKE SEMAGLUTIDE FOR WEIGHT LOSS?
Currently, Semaglutide is only FDA-approved for obesity and to help with blood sugar control in type-2 diabetes and to lower the risk of major cardiovascular events (like heart attack and stroke) in people with both type-2 diabetes and heart disease. If you are taking Semaglutide for either of these reasons, you'll take it as directed by your healthcare provider since you are using it to manage a chronic condition. But if you do not have type-2 diabetes and are looking to try Semaglutide to help you lose weight, we'll have a better idea of long-term safety once the FDA reviews data for this new indication. What we do know is that study participants received treatment for a period of 68 weeks (about 1.5 years) during each of the four trials conducted by the company.
WHAT IS THE STARTING DOSE OF SEMAGLUTIDE FOR WEIGHT LOSS?
All patients start on the lowest dose of Semaglutide at 0.25mgs injected subcutaneously into belly fat every week. All patients increase by 0.25mgs every two weeks as tolerated (slower if nauseous). The dosing being studied for weight loss is 2.5 mg once weekly, which is currently higher than the doses approved in diabetes. Semaglutide is being studied in different populations: people with a body mass index (BMI) greater than or equal to 30 kg/m 2 alone or 27 kg/m 2 with at least one weight-related comorbidity (diabetes excluded).
IS SEMAGLUTIDE A TYPE OF INSULIN?
No, Semaglutide is not a type of insulin or a substitute for insulin. Semaglutide does stimulate your pancreas to release insulin when glucose (sugar) is present. Because Semaglutide relies upon your body's own insulin to have this effect, Semaglutide isn't used when your pancreas can't make insulin, such as in patients with type-1 diabetes.
IS SEMAGLUTIDE A STIMULANT?
No, Semaglutide is not a stimulant. While other weight loss medications, like phentermine, have stimulating effects that help curb your appetite, Semaglutide works differently (see above).
IS SEMAGLUTIDE SAFE?
Yes. Semaglutide is considered to be safe and effective when used as indicated. However, safe doesn't mean there aren't risks. Semaglutide also carries a boxed warning about thyroid C-cell tumors occurring in rodents (with unknown risk in humans). Semaglutide shouldn't be used if you or your family have a history of certain thyroid cancers. Semaglutide should not be used in people with type-1 diabetes or a history of pancreatitis. Semaglutide should be used cautiously for people on other blood sugar lowering medications.
IS SEMAGLUTIDE COVERED BY MY INSURANCE?
No. Semaglutide is not covered by insurance for people who are not diabetic type-2. However, you can get this medication prescribed as part of this Semaglutide Weight Loss Program.
WHERE WILL I BUY MY SEMAGLUTIDE?
Once enrolled in the program and evaluated by our board certified physician, the medication and supplies will be shipped to your home or to the practice. The cost of the medication is included in the program.
IS SEMAGLUTIDE APPROVED BY THE FDA?
WHAT ARE THE KNOWN SIDE EFFECTS OF SEMAGLUTIDE?
The common side effects of Semaglutide are:
- Stomach pain
Effects like nausea and diarrhea being the most common.
ARE THERE ANY SIGNIFICANT HEALTH RISKS ASSOCIATED WITH USING SEMAGLUTIDE?
Yes. Semaglutide may cause rare side effects, including:
- Prolonged vomiting. Patients on Semaglutide can develop gastroparesis where thestomach stops moving, and patients vomit considerably. This can lead todehydration and electrolyte imbalances. Stop using Semaglutide and call yourhealthcare provider right away if you have vomiting that persists more than a day.
-Inflammation of your pancreas (pancreatitis). Stop using Semaglutide and call yourhealthcare provider right away if you have severe pain in your stomach area(abdomen) that will not go away, with or without vomiting. You may feel the painfrom your abdomen to your back.
- Changes in vision. Tell your healthcare provider if you have changes in vision during treatment with Semaglutide
-Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Semaglutide with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include: dizziness or lightheadedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery.
- Kidney problems (kidney failure). In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse.It is important for you to drink fluids to help reduce your chance of dehydration.
- Serious allergic reactions. Stop using Semaglutide and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat.
WHAT HAPPENS AFTER THE 6 WEEK WEIGHT LOSS PROGRAM?
Weight loss has to be safely guided: it is not safe to lose too much weight in a short period of time. We will ensure that your dose is optimal and specifically curated based on your response. Our complete program can last 20 weeks or more. Depending on your goal weight; most patients will need more than six weeks. After your six weeks you can be enrolled in our monthly membership program at an additional cost.
DO I NEED TO FOLLOW A DIET OR EXERCISE?
You don't need to adhere to a rigorous, prescribed diet in order to lose weight, but you will do it faster if you consume a well-balanced diet rich in whole foods, lean proteins, healthy fats, and fiber. You'll develop better behaviors that will assist you in maintaining your weight loss.
For long-term health, it is our intention to establish good habits. Although it is not required, we strongly advise exercise. Exercise is important for maintaining good health, and patients have said that when they begin to lose weight, it gets easier.